Skeletal Muscle-2nd Edition

Additional Information

Part I: Structure and Development
Chapter 1. Muscle Architecture and Muscle Fiber Anatomy

• Muscle Architecture
  
• Muscle Connective Tissue
  
• Basement Membrane
  
• Plasmalemma
  
• Myofibrils
  
• Tubular Systems
  
• Nuclei and Mitochondria
  
• Applied Physiology

• General Features of Motoneurons
  
• Motoneuron Soma
  
• Cytoskeletal Proteins in the Motoneuron
  
• Axon, Dendrites, and Glia
  
• Applied Physiology

• General Features of the Neuromuscular Junction
  
• Muscle Fiber Acetylcholine Receptors
  
• The Basement Membrane at the Neuromuscular Junction
  
• Axon Terminal
  
• Applied Physiology

• The Muscle Spindle
  
• The Golgi Tendon Organ
  
• Free Nerve Endings
  
• Role of Muscle Receptors During Locomotor Activity
  
• Applied Physiology

• Step 1: Mesoderm Is Induced from Ectoderm
  
• Step 2: A Portion of Mesoderm Forms Somites, Then Develops Into Skeletal Muscle
  
• Step 3: The Myogenic (Muscle Forming) Cells Proliferate and Then Differentiate
  
• Step 4: The Body Plan Is Laid Down
  
• Step 5: Muscles Are Assembled
  
• Postnatal Development of Muscle
  
• Applied Physiology

• Step 1: Inductive Signals Pass From Mesoderm to Ectoderm
  
• Step 2: The Neural Tube Forms From Thickening and Invagination of the Dorsal Ectoderm
  
• Step 3: Nerve Cells Proliferate and Then Migrate
  
• Step 4: Axons Grow Out From the Spinal Cord Along the Extracellular Matrix
  
• Step 5: The Axons Establish Connections With the Muscle Fibers
  
• Step 6: Redundant Synapses and Motoneurons Are Eliminated
  
• Applied Physiology

• General Properties of Channels and Pumps
  
• Sodium Channels
  
• The Sodium Pump (Na+-K+ Pump)
  
• Potassium Channels
  
• Calcium Channels and Pumps
  
• Calcium-Binding Proteins
  
• Calcium Pumps
  
• Anion Channels
  
• Applied Physiology

• Confirmation and Categorization of Axoplasmic Transport
  
• Applied Physiology

• Resting Membrane Potential
  
• The Action Potential
  
• Applied Physiology

• Acetylcholine Release
  
• Postsynaptic Events
  
• Applied Physiology

• Sliding Filament Theory of Muscle Contraction
  
• The Cross-Bridge Theory of Skeletal Muscle
  
• The Key Contractile Proteins: Myosin and Actin
  
• Excitation-Contraction Coupling
  
• The Contractile Response
  
• The Length Dependence of Force
  
• Dynamic Contractions
  
• Applied Physiology

• Organization of Motor Units
  
• Physiological and Biochemical Properties of Motor Units
  
• Classification of Motor Units
  
• Applied Physiology

• Detection of Motor Unit Activation
  
• The Size Principle
  
• Maximal Voluntary Contraction
  
• Applied Physiology

• Energy Required for Muscle Contraction
  
• Replacing Adenosine Triphosphate
  
• Integration of the Metabolic Systems
  
• Regulation of the Metabolic Systems
  
• How Much Energy Is Needed?
  
• Applied Physiology

• Defining Fatigue
  
• Central Fatigue
  
• Peripheral Fatigue
  
• Excitation-Contraction Coupling Failure
  
• Biochemical Changes in Muscle Fibers
  
• Recovery From Fatigue
  
• Applied Physiology

• Changes in Motor Axons and Neuromuscular Junctions
  
• Changes in Muscle Fibers
  
• Applied Physiology

• Nerve Regeneration
  
• Collateral Reinnervation
  
• Changes in the Muscle Fibers Following Reinnervation
  
• Motor Unit Properties Following Reinnervation
  
• Applied Physiology

• Motoneuron Effects on Muscle
  
• Muscle Effects on Motoneurons
  
• Applied Physiology

• Studies in Human Subjects
  
• Studies in Animals
  
• Applied Physiology

• Muscle Strength and Power
  
• Human Endurance Training
  
• Training Studies in Animals
  
• Adaptive Changes in DNA and RNA Processing
  
• Applied Physiology

• Muscle Contraction-Induced Damage
  
• Muscle Injury From External Causes
  
• Applied Physiology

• Changes in Muscle With Aging
  
• Motoneuron Changes in Aging
  
• Changes in Axons and Neuromuscular Junctions
  
• Applied Physiology

Developer / Author(s)

Brian R. MacIntosh, PhD, is associate dean of the graduate program and professor for the faculty of kinesiology at the University of Calgary in Alberta, Canada. MacIntosh is on the cutting edge of research in skeletal muscle and has published more than 50 papers and numerous book chapters in muscle and exercise physiology. He has been teaching undergraduate and graduate courses in these areas for 25 years and is a member of the Canadian Society for Exercise Physiology, the Canadian Physiological Society, the American Physiological Society, the American College of Sports Medicine, the Biophysical Society, and the Human Powered Vehicles Association. He is also an associate editor for the Canadian Journal of Applied Physiology and a former board member for the Canadian Society for Exercise Physiology.

Phillip Gardiner, PhD, is director of the Health, Leisure & Human Performance Research Institute at the University of Manitoba in Winnipeg, Manitoba. He is also an adjunct professor of physiology, a member of the Spinal Cord Research Center in the faculty of medicine at the University of Manitoba, and a Canada Research Chair, a position given to internationally renowned researchers. Gardiner is past president of the Canadian Society for Exercise Physiology and previous coeditor in chief of the Canadian Journal of Applied Physiology. He has published extensively in the area of neuromuscular adaptations and authored the book Neuromuscular Aspects of Physical Activity.

Alan J. McComas, MB, is emeritus professor of medicine (in neurology) at McMaster University in Hamilton, Ontario. McComas has more than 40 years of research experience in nerve and muscle. Among his accomplishments in research are devising a method for estimating the number of human motor units in human muscle, showing the importance of the electrogenic sodium pump in delaying fatigue, and carrying out early microelectrode studies of human muscle fibers. He has held named lectureships and is a member of the Society for Neuroscience.

Editor(s)

Reviews

“…the leading authority on the structure, electrophysiology, and adaptability of human skeletal muscle.”
www.SirReadaLot.org

"Overall, this text will serve as a solid, comprehensive text for undergraduates and graduate students, and as a practical reference for its professional audience."
Coral Murrant
Department of Human Health and Nutritional Science
University of Guelph

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